In this project, we present a combination of two different technologies on the field of regenerative medicine and nanoparticles:
- A nanostructured fibrin-agarose hydrogel which has proven to be effective for the tissue-engineered construction of artificial human skin.
- The addition of two types of NPs to the bioengineered human skin to improve its properties as follow:
- Nanoencapsulated rhEGF, which will foster cell proliferation reducing the manufacturing time of the skin substitute and promoting a faster regeneration of the injured tissue.
- Nanoencapsulated antibiotics, which will decrease bacterial load of skin substitutes to improve grafting.
All this will address common disavadvantages of synthetic skin substitutes: high bacterial infection risk, low biological activity, low regenerative effectiveness and low immediate availability.