Paving the way of translating functionalized tissues to the clinics

A novel milestone has been accomplished in the NanoGSkin project. Under the title “Generation of a novel human dermal substitute functionalized with antibiotic‑loaded nanostructured lipid carriers (NLCs) with antimicrobial properties for tissue engineering”, a paper has been published with the results of the joint research work performed by Keralty and the Tissue engineering research group of our coordinator institution, ibs.Granada.

In this paper, researchers present the results of combining the artificial skin substitute developed by ibs.Granada with the antibiotic-loaded NPs optimally synthesized by Keralty. Interesting data proved that :

  • The novel functionalized skin substitute (FSS) has strong antibacterial effect on Pseudomonas bacteria cultures, directly proportional to the NLC concentration.
  • FSS demonstrated that neither cell viability nor cell proliferation were affected by functionalization with NLCs, confirming the high biocompatibility of these nanoparticles.
  • FSS resemble the native tissues not only at histological level, but also from a biomechanical standpoint.

In conclusion, these results demonstrated that fibrin-agarose skin substitutes can be functionalized with antibiotic-loaded NLCs, without affecting the biological and biomechanical properties of the biomaterial but incorporating an antibacterial effect. The biocompatibility and efficacy of the FSS open the door to future clinical use of functionalized tissues, an innovative approach to treat burn patients who usually suffer from bacterial infections.

The paper was published in the Journal of Nanobiotechnology as an open access paper to support the Responsible Research and Innovation policy, and it can be freely consulted at this link or at our Media Center.

 

 

Cite this article

Chato-Astrain, J., Chato-Astrain, I., Sánchez-Porras, D. et al. Generation of a novel human dermal substitute functionalized with antibiotic-loaded nanostructured lipid carriers (NLCs) with antimicrobial properties for tissue engineering. J Nanobiotechnol 18, 174 (2020). https://doi.org/10.1186/s12951-020-00732-0